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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RAF1 All Species: 44.85
Human Site: S533 Identified Species: 89.7
UniProt: P04049 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04049 NP_002871.1 648 73052 S533 S F Q S D V Y S Y G I V L Y E
Chimpanzee Pan troglodytes XP_001155232 648 73032 S533 S F Q S D V Y S Y G I V L Y E
Rhesus Macaque Macaca mulatta XP_001086034 615 69495 S500 S F Q S D V Y S Y G I V L Y E
Dog Lupus familis XP_859234 648 72974 S533 S F Q S D V Y S Y G I V L Y E
Cat Felis silvestris
Mouse Mus musculus Q99N57 648 72899 S533 S F Q S D V Y S Y G I V L Y E
Rat Rattus norvegicus P11345 648 72910 S533 S F Q S D V Y S Y G I V L Y E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P05625 647 73106 S533 S F Q S D V Y S Y G I V L Y E
Frog Xenopus laevis P09560 638 71941 S524 S F Q S D V Y S Y G I V L Y E
Zebra Danio Brachydanio rerio NP_571514 643 72503 S529 S F Q S D V Y S Y G I V L F E
Tiger Blowfish Takifugu rubipres NP_001033078 663 74935 S549 S F Q S D V Y S Y G I V L F E
Fruit Fly Dros. melanogaster P11346 782 88616 A656 S F Q S D V Y A F G I V M Y E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q07292 813 90389 S670 T P Q S D V Y S F G I C M Y E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 94.9 98.7 N.A. 97.6 98.3 N.A. N.A. 94.5 85.3 75.1 80.5 37.4 N.A. 36 N.A.
Protein Similarity: 100 100 94.9 99.2 N.A. 98.3 98.4 N.A. N.A. 97.6 90.7 83.9 87 52.9 N.A. 51 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 100 93.3 93.3 80 N.A. 66.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 100 100 100 100 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 % E
% Phe: 0 92 0 0 0 0 0 0 17 0 0 0 0 17 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 84 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 92 0 0 100 0 0 0 92 0 0 0 0 0 0 0 % S
% Thr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 100 0 0 0 0 0 92 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 100 0 84 0 0 0 0 84 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _